Welcome to Toshi Taniguchi Lab
DNA repair and cancer
Genomic instability is a hallmark of most human cancers and is thought to be a main impetus behind the conversion of premalignant cells into a more malignant state through the acquisition of multiple somatic mutations. Defects in the DNA-damage response and DNA repair are probable major contributors to genomic instability in cancer and also are likely to play a critical role in the sensitivity of cancer cells to chemotherapeutic drugs. Thus, it is important to elucidate the cellular processes involved in DNA-damage response/DNA repair in order to achieve greater understanding of cancer and to develop new diagnostic and therapeutic strategies.
The long-term objectives of our research are
1) to elucidate molecular mechanism of DNA repair/DNA damage response pathways and their involvement in carcinogenesis, and
2) to refine diagnosis and therapy of patients with cancer or genetic diseases by utilizing such information.
We are especially interested in two DNA repair/DNA damage response pathways:
1) the Fanconi anemia (FA)-BRCA pathway, and
2) the DGCR8-mediated UV response pathway.
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